Publications
Recent highlights
Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health
Jolien Perneel, Miranda Lastra Osua, Sara Alidadiani, Nele Peeters, Linus De Witte, Bavo Heeman, Simona Manzella, Riet De Rycke, Mieu Brooks, Ralph B. Perkerson, Elke Calus, Wouter De Coster, Manuela Neumann, Ian R. A. Mackenzie, Debby Van Dam, Bob Asselbergh, Tommas Ellender, Xiaolai Zhou & Rosa Rademakers
Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U
Sara Alidadiani, Júlia Faura, Sarah Wynants, Nele Peeters, Marleen Van den Broeck, Linus De Witte, Rafaela Policarpo, Simon Cheung, Cyril Pottier, Nikhil B. Ghayal, Merel O. Mol, Marka van Blitterswijk, Evan Udine, Mariely DeJesus-Hernandez, …, Rosa Rademakers
Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes
Cristina T. Vicente, Tejasvi Niranjan, Elise Coopman, Júlia Faura, Sara Alidadiani, Claudia Schrauwen, Billie J. Matchett, Bavo Heeman, Marleen Van den Broeck, Wouter De Coster, Thuy Nguyen, Julie S. Lau, Saurabh Baheti, Tim de Pooter, Peter De Rijk, Mojca Strazisar, …, Rosa Rademakers
Analysis of the splicing landscape of the frontal cortex in FTLD-TDP reveals subtype specific patterns and cryptic splicing
Júlia Faura, Bavo Heeman, Cyril Pottier, Matthew C Baker, Mariely DeJesus-Hernandez, Fahri Küçükali, Laura Heiß, Sarah Wynants, Marleen Van den Broeck, Peter De Rijk, Tim De Pooter, Geert Joris, NiCole A Finch, Yan Asmann, Mojca Strazisar, ... , Rosa Rademakers
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
Cyril Pottier, Fahri Küçükali, Matt Baker, Anthony Batzler, Gregory D Jenkins, Marka van Blitterswijk, Cristina T Vicente, Wouter De Coster, Sarah Wynants, Pieter Van de Walle, Owen A Ross, Melissa E Murray, Júlia Faura, Stephen J Haggarty, Jeroen GJ van Rooij, Merel O Mol, Ging-Yuek R Hsiung, Caroline Graff, Linn Öijerstedt, Manuela Neumann, Yan Asmann, Shannon K McDonnell, Saurabh Baheti, ... , Rosa Rademakers
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration
Rowan Saloner, Adam M Staffaroni, Eric B Dammer, Erik CB Johnson, Emily W Paolillo, Amy Wise, Hilary W Heuer, Leah K Forsberg, Argentina Lario-Lago, Julia D Webb, Jacob W Vogel, Alexander F Santillo, Oskar Hansson, Joel H Kramer, Bruce L Miller, ... , Rosa Rademakers, ... , ALLFTD Consortium
Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics
Sarah Mizielinska, Guillaume M Hautbergue, Tania F Gendron, Marka van Blitterswijk, Orla Hardiman, John Ravits, Adrian M Isaacs, Rosa Rademakers